Introduction

An introduction to drug checking and this implementation workbook.

Introduction

Welcome to Drug Checking: An Implementation Workbook by Drug Checking For The People. This resource is intended for harm reduction advocates, administrators, program directors, and anyone who wants to start building a point-of-care and community-based drug checking service using an infrared spectrometer. This workbook will walk through the steps required to start a drug checking service: from conceptualizing the program, incorporating community feedback, purchasing equipment, and hiring staff, through the implementation of the service and continuing education. Questions and space for reflection are included throughout to help navigate the complicated and intricate nuances of building a drug checking program from the ground up. Example materials and resources are incorporated to provide a solid foundation from which to build. This workbook is not intended as a technician training resource and should not replace any part of the technician training process (contact Remedy Alliance for more information about technician training). This workbook will focus on community based drug checking, or drug checking embedded within programs or services that are frequently accessed by people who use opioids and are at a high risk of overdose, such as syringe service programs (SSPs), safe consumption sites (SCS) and overdose prevention centers (OPCs), or other harm reduction programs. Though there is a significant amount of overlap between drug checking in opioid dominant contexts and other festival, nightlife, or pop-up event drug checking, there are other unique characteristics and considerations for those other settings that are beyond the scope of this workbook. 

We hope that this workbook will give programs a solid foundation from which to build, but drug checking is a complicated intervention and many concepts, topics, and details simply cannot be taught through a workbook. We hope that alongside this resource, programs will be in regular  dialogue with experts in the field as well as with people who use drugs in their community. Remedy Alliance offers drug checking drop-in hours on the 2nd and 4th Wednesday of the month and there are many complementary resources available from leaders in the drug checking field to guide the implementation of a drug checking service. See Continuing Education for more information.

We also want to highlight that drug checking is a new intervention and there is still much that we don’t know. Involving people who use drugs in every facet of program design will always be best practice, but we hesitate to claim a monopoly on operational 'best practices'. The resources and guidelines we explore here are what we consider 'effective practices that are continually being improved upon as we gain experience and learn more.' It's a mouthful, but it's import to understand that any new drug checking program will be entering the fray to collectively iterate these 'effective practices' into 'best practices'. We encourage you to be creative and innovative, to think outside the box and, most importantly, to prioritize the voices and ideas of people who use drugs.

What is Drug Checking?

Drug checking at its most distilled is analyzing the drugs a person plans to consume (or has already consumed) to give them information about the contents of their substance. Drug checking helps to identify unexpected or unwanted components in someone’s drugs, as well as expected components in unexpected amounts. With better information about what is in their drugs, people can choose whether or not they want to consume it, and if they choose to consume it, they can receive harm reduction strategies specific to the contents of their drugs and their personal context. Most importantly, drug checking validates the human right to self-determination, bodily autonomy, and the pursuit of pleasure—a major motivator for engaging in drug use.

Drug checking employs a variety of different technologies. Reagent testing, immunoassay (test) strips, and spectrometers such as a Fourier Transform Infrared (FTIR) spectrometer are all used in point-of-care settings. More advanced laboratory equipment like gas chromatography mass spectrometers (GC/MS), liquid chromatography mass spectrometers (LC/MS), and others are accessed through mail-in services, either as a stand-alone service or in partnership with a community-based drug checking program. Each technology has strengths and limitations and the types of technologies a drug checking program uses will be based on that program’s unique circumstances and needs. This workbook focuses specifically on the implementation of FTIR spectrometers in a point-of-care setting, coupled with immunoassay strips and secondary verification at an off-site laboratory.

Why Do We Need It?

Within the context of drug prohibition and criminalization, the unregulated drug supply has become increasingly erratic and unpredictable. This unpredictability is a major driver of drug-related harms, leading to unimaginable increases in the number of overdose deaths, non-fatal overdoses, soft tissue damage and infection, and other adverse physical and mental health effects1. The drug supply responds to countless factors such as changes in demand, the availability, legality, and cost of ingredients, arrests and drug busts, and both foreign and domestic policy2. The North American opioid supply, for example, is currently shifting between combinations of substances such as xylazine, nitazenes, benzodiazepines, heroin, fentanyl analogs and other novel substances. This parallels the challenges experienced by psychedelics enthusiasts with the emergence of novel psychoactive substances, the resurgence of lesser-known psychedelics, and the nuances between different drugs within the same family (e.g., 2C-B, 2C-I, 2C-P). This perpetual evolution of the drug supply necessitates constant education and learning by community members who use these substances.  By adding drug checking to the suite of harm reduction tools and resources already available, programs can start to gain insight into their regional drug supply and work towards reducing the unpredictability of the drug supply. 

Historically, misinformation about drugs and the drug supply have been used to stigmatize and marginalize communities of color, specifically Black and brown communities within the United States3. This intentional misinformation and criminalization of drugs, based not on their actual risk but on who was perceived to be using that drug, was used to justify over-policing and mass-incarceration of communities of color. This played out in the 1960s with the Nixon administration; heavily criminalizing crack cocaine was an intentional political move intended to disrupt black communities4. Misinformation about the effects of crack cocaine were circulated to justify the extreme policies and punishments related to crack use. Today, we still live in a world that is full of uncertainties and misinformation about drugs and the drug supply.  Often the information we do have is not accessible to the communities most impacted by the unregulated and erratic drug supply. Without drug checking programs, the information we have about the drug supply comes from sources such as Medical Examiners offices, toxicology screens, and the Drug Enforcement Agency (DEA) and drug seizure data. These data are rarely if ever translated in a way that is relevant, timely, and understandable to people who use drugs, much less made accessible. Even as drug checking becomes more available, this intervention is at risk of being co-opted by academic institutions, healthcare conglomerates, health departments, and other entities that have a track record of gatekeeping information or prioritizing surveillance over service provision. Through this resource, we hope to make drug checking more accessible and available to grassroots organizations, harm reduction programs, and people who use drugs. We believe that drug checking should live within the community and that the best drug checking programs are those that are built by or co-created with people who use drugs. Through our work, we affirm the expertise of people who use drugs, people of color, and grassroots harm reduction programs by investing in their leadership within the drug checking space. Our goal is nothing less than drug checking by the people and drug checking for the people.

The unintentional transfer of a compound from one object or place to another.

Needs-based syringe distribution provides people who inject drugs(PWID) access to the number of syringes they need to ensure that a new, sterile syringe is available for each injection. A needs-based approach provides sterile syringes with no restrictions, including no requirement to return used syringes. https://stacks.cdc.gov/view/cdc/112935

A community advisory board (CAB) is a collective group of community members and representatives that provide suggestions, feedback, and directives to an organization. They advocate for the preferences and desires of the community, and help to ensure that the services a program is offering actually meets the community's needs.

Next Distro Definition of Drug Users Unions:

Drug user unions band together for connection, protection, and to change systems that control and punish people who use drugs. They provide opportunities to make changes on social, legal, and health issues that impact drug users. Similar to labor unions, drug user unions work together to solve a problem that members of the group are facing.They can connect you to resources, provide a space to talk about your use, and opportunities for strengthening the rights of people who use drugs like you. Drug user unions recognize the expertise of people who use drugs and put the power in their hands.

https://nextdistro.org/resources-collection/fight-back-drug-user-unions-how-drug-users-are-working-together-for-their-rights

WHP: Drugs of Abuse Testing
https://www.whpm.com/xylazine

DanceSafe Xylazine Test Strips

https://dancesafe.org/xylazine-test-strips/

Godkhindi, P., Nussey, L. & O’Shea, T. “They're causing more harm than good”: a qualitative study exploring racism in harm reduction through the experiences of racialized people who use drugs. Harm Reduct J19, 96 (2022). https://doi.org/10.1186/s12954-022-00672-y

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-022-00672-y

Lopez, A. M., Thomann, M., Dhatt, Z., Ferrera, J., Al-Nassir, M., Ambrose, M., & Sullivan, S. (2022). Understanding racial inequities in the implementation of harm reduction initiatives. American journal of public health, 112(S2), S173-S181.

https://ajph.aphapublications.org/doi/full/10.2105/AJPH.2022.306767

Dasgupta, N., & Figgatt, M. C. (2022). Invited commentary: drug checking for novel insights into the unregulated drug supply. American Journal of Epidemiology, 191(2), 248-252.

McCrae, K., Tobias, S., Grant, C., Lysyshyn, M., Laing, R., Wood, E., & Ti, L. (2020). Assessing the limit of detection of Fourier‐transform infrared spectroscopy and immunoassay strips for fentanyl in a real‐world setting. Drug and alcohol review, 39(1), 98-102.

Gozdzialski, L., Wallace, B., & Hore, D. (2023). Point-of-care community drug checking technologies: an insider look at the scientific principles and practical considerations. Harm Reduction Journal, 20(1), 39.

Brandeis University: Massachusetts Drug Supply Data Stream

https://heller.brandeis.edu/opioid-policy/community-resources/madds/index.html

Washington State Community Drug Checking Network

https://adai.uw.edu/wordpress/wp-content/uploads/THE_DC_Network_Infosheet.pdf

To Combat the Opioid Crisis, Expand Drug Checking Programs
https://www.wired.com/story/to-combat-the-overdose-crisis-expand-drug-checking-programs/

New York State Department of Health Announces Drug Checking Programs

https://www.health.ny.gov/press/releases/2023/2023-10-23_drug_checking_programs.htm

British Columbia Centre on Substance Use: What is Drug Checking

https://drugcheckingbc.ca/what-is-drug-checking/

We Are the Loop: Our History

https://wearetheloop.org/our-history

Nixon Adviser Admits War on Drugs Was Designed to Criminalize Black People

https://eji.org/news/nixon-war-on-drugs-designed-to-criminalize-black-people/

Race and the War on Drugs

https://www.nacdl.org/Content/Race-and-the-War-on-Drugs

Otiashvili D, Mgebrishvili T, Beselia A, Vardanashvili I, Dumchev K, Kiriazova T, Kirtadze I. The impact of the COVID-19 pandemic on illicit drug supply, drug-related behaviour of people who use drugs and provision of drug related services in Georgia: results of a mixed methods prospective cohort study. Harm Reduct J. 2022 Mar 9;19(1):25. doi: 10.1186/s12954-022-00601-z. PMID: 35264181; PMCID: PMC8906357.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906357/

Emerging Drug Trends and Prevention

https://www.carnevaleassociates.com/our-work/emerging-drug-trends-prevention-issue-brief.html

Ray, B., Korzeniewski, S. J., Mohler, G., Carroll, J. J., Del Pozo, B., Victor, G., ... & Hedden, B. J. (2023). Spatiotemporal analysis exploring the effect of law enforcement drug market disruptions on overdose, Indianapolis, Indiana, 2020–2021. American journal of public health, 113(7), 750-758.

https://ajph.aphapublications.org/doi/10.2105/AJPH.2023.307291

Also referred to as point-of-care drug checking, community based drug checking refers to drug checking that is cited within overdose prevention centers, SSPs, and other harm reduction or community health settings. Compared to nightlife or pop-up drug checking, community based drug checking is more likely to be accessed by people who are structurally vulnerable to the harms of the War on Drugs and may be experiencing homelessness, complex medical concerns, and more chaotic substance use.

Within the context of drug checking, cross-reactivity refers to when a test responds inappropriately to the presence of a secondary compound that is not the primary target substance. For example, the presence of diphenhydramine (the active ingredient in Benadryl) can cause a false-positive result on a fentanyl test strip.

A memorandum of understanding (MOU) is a non-binding agreement between two or more parties that outlines how they will work together. MOUs are also known as letters of intent (LOIs) or memorandums of agreement (MOAs), and sometimes are the first step towards a formal contract.

Immunoassay strips are used to identify the presence or absence of a particular compound. The use specific antibodies to bind to the compound of interest. Immunoassay strips only give a positive or negative answer and do not indicate anything about how much of a particular compound is present. Examples of immunoassay strips commonly used in drug checking include fentanyl test strips, xylazine test strips, and benzodiazepine test strips, although tests are available for many other types of drugs.

The lowest concentration that can be confidently detected by an analytical instrument or technique.

An analytical instrument used to identify different compounds. Infrared spectroscopy uses infrared light to scan a sample, and then measures how the infrared light interacts with the various compounds in the sample.

A local drug supply refers to the localized aspects of drug availability within a specific area, encompassing unique variations in available drugs, adulterants, and distribution methods. These are impacted by regional law enforcement dynamics, community relationships, and targeted policies or interventions specific to that area.

Overdose Data to Action (OD2A) supports jurisdictions in implementing prevention activities and in collecting accurate, comprehensive, and timely data on nonfatal and fatal overdoses and in using those data to enhance programmatic and surveillance efforts. OD2A focuses on understanding and tracking the complex and changing nature of the drug overdose crisis by seamlessly integrating data and prevention strategies.

Following lawsuits against major pharmaceutical companies such as Perdue Pharma, opioid manufacturers and distributers are paying more than $54 billion in restitution for their role in the opioid overdose crisis. Much of this money has or will be given directly to state, county, or city governments but there is little guidance in how the money is to be spent.

An adulterant is a substance added to a drug to increase the bulk or weight of a drug, or to enhance the effects or the delivery of the drug in some way. Examples of common adulterants include xylazine, caffeine, diphenhydramine, and levamisole.

A method of determining the presence or absence of a specific compound using specific chemicals to elicit color changes within a solution. In drug checking, colorimetric analysis, also known as reagent testing, is used to assess for the presence or absence of a specific drug of interest. Results of the test are interpreted based on the observed color changes.