Module One: History of Drug Checking

A brief history of drug checking in the United States and around the world.

The Origins of Drug Checking

For as long as humans have used drugs, whether as medicine, spiritual practice, or in the pursuit of pleasure, they have checked drugs. By using sight, smell, and taste alongside the experience of using it, the body was the original drug checking technology. Technologies able to analyze drug samples have existed for decades, but until recently these technologies have been predominantly used as tools of surveillance, law enforcement and prohibition. Information about the drug supply has existed, but generally has not circled back to communities of people who use drugs with the intention of improving their health and wellbeing.

Modern drug checking as we know it was first popularized through festival and nightlife events. Colorimetric analysis, or reagent testing, was used at festivals and rave scenes across Europe in the 1970s to identify unexpected adulterants in psychedelic and other nightlife drugs. In the United States, DanceSafe was an early pioneer in this field and helped to expand reagent drug checking beginning in the early 1990s. Also in the 1990s, Erowid launched DrugsData (formerly EcstasyData), a drug checking service using advanced analytical chemistry equipment like GC/MS to test drug samples that were mailed from across the country. Energy Control, a pioneering harm reduction and drug checking service out of Spain, was founded in 1997 and mentored the development of Échele Cabeza, Latin America’s largest harm reduction and drug checking service based in Bogotá Colombia. Échele Cabeza in turn has mentored several programs across Latin America such as Proyeco Soma in Peru and Checa tu Sustancia in Mexico City.

Reagents and colorimetric testing

2010s and the beginning of FTIR

Point-of-care drug checking with an FTIR spectrometer began at festivals in the UK in the early-to-mid-2010s. The Loop, an organization born from an interest in the intersection of harm reduction and music, began implementing FTIR spectrometer testing of drug samples at festivals in the UK1. The Loop remains a leader in drug checking and is an active part of many different drug checking communities today. In 2017 and early 2018, in response to the escalating overdose crisis in British Columbia, the British Columbia Centre on Substance Use (BCCSU), the Substance program at the University of Victoria, and other programs across Canada implemented direct service FTIR-based drug checking for opioid- and other drug-using communities in British Columbia and other regions of the country2. This model was born out of elements from The Loop’s pioneering work with FTIR and ANKORS’ (AIDS Network Kootenay Outreach and Support Society) music festival model. Early technicians in Canada were trained to use FTIR spectrometers to analyze all types of drug samples, but mainly checked opioids, methamphetamine, and cocaine. Drug checking services were embedded within existing harm reduction programs or in supervised consumption sites (SCS; also known as overdose prevention centers (OPCs)) and services were delivered alongside other harm reduction services. 

Community-based drug checking in the United States is largely based on the model developed by Canadian colleagues at BCCSU, ANKORS, and Substance. With support from technician trainers from the BCCSU, the Chicago Recovery Alliance (CRA) began providing FTIR-based drug checking services in 2019, followed shortly by the Massachusetts Drug Supply Data Stream at Brandeis University and the AHOPE program at the Boston Public Health Commission. A small group of advocates, researchers, and leaders in the harm reduction field came together in Chicago in 2019 to form the Alliance for Collaborative Drug Checking (ACDC), an international brain trust dedicated to the global advancement and expansion of drug checking. ACDC now has over 600 members from more than 10 countries and hosts an annual learning summit featuring drug checking experts from around the world. 

Innovating for the future

The past five years have seen immense growth and expansion related to drug checking. Kykeon Analytics in Spain has started accepting mailed samples of drugs and has built their own FTIR library. The Substance program at the University of Victoria has pioneered using a tandem paper-spray mass spectrometer and FTIR approach, and are leaders in innovative approaches to data analysis, software and increasing access to drug checking. Brandeis University built StreetCheck, a data collection software made specifically for drug checking. The University of North Carolina’s StreetSafe program now offers secondary verification lab testing for over 22 programs across the United States. The Center for Forensic Research and Evaluation (CFSRE), the National Institute of Standards and Technology (NIST) and other labs have joined DrugsData and UNC to provide secondary verification to other programs across the country and are beginning to provide quantification information to drug checking programs as well. These advancements and so many more are shared by experts in the field during the annual ACDC learning summit that takes place in May. For more information about the annual learning summit, email acdchecking@gmail.com.

ACDC members at the Alliance for Collaborative Drug Checking community session at the 2023 Drug Policy Alliance Reform conference in Phoenix, Arizona. 

Related Resources

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The unintentional transfer of a compound from one object or place to another.

Needs-based syringe distribution provides people who inject drugs(PWID) access to the number of syringes they need to ensure that a new, sterile syringe is available for each injection. A needs-based approach provides sterile syringes with no restrictions, including no requirement to return used syringes. https://stacks.cdc.gov/view/cdc/112935

A community advisory board (CAB) is a collective group of community members and representatives that provide suggestions, feedback, and directives to an organization. They advocate for the preferences and desires of the community, and help to ensure that the services a program is offering actually meets the community's needs.

Next Distro Definition of Drug Users Unions:

Drug user unions band together for connection, protection, and to change systems that control and punish people who use drugs. They provide opportunities to make changes on social, legal, and health issues that impact drug users. Similar to labor unions, drug user unions work together to solve a problem that members of the group are facing.They can connect you to resources, provide a space to talk about your use, and opportunities for strengthening the rights of people who use drugs like you. Drug user unions recognize the expertise of people who use drugs and put the power in their hands.

https://nextdistro.org/resources-collection/fight-back-drug-user-unions-how-drug-users-are-working-together-for-their-rights

WHP: Drugs of Abuse Testing
https://www.whpm.com/xylazine

DanceSafe Xylazine Test Strips

https://dancesafe.org/xylazine-test-strips/

Godkhindi, P., Nussey, L. & O’Shea, T. “They're causing more harm than good”: a qualitative study exploring racism in harm reduction through the experiences of racialized people who use drugs. Harm Reduct J19, 96 (2022). https://doi.org/10.1186/s12954-022-00672-y

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-022-00672-y

Lopez, A. M., Thomann, M., Dhatt, Z., Ferrera, J., Al-Nassir, M., Ambrose, M., & Sullivan, S. (2022). Understanding racial inequities in the implementation of harm reduction initiatives. American journal of public health, 112(S2), S173-S181.

https://ajph.aphapublications.org/doi/full/10.2105/AJPH.2022.306767

Dasgupta, N., & Figgatt, M. C. (2022). Invited commentary: drug checking for novel insights into the unregulated drug supply. American Journal of Epidemiology, 191(2), 248-252.

McCrae, K., Tobias, S., Grant, C., Lysyshyn, M., Laing, R., Wood, E., & Ti, L. (2020). Assessing the limit of detection of Fourier‐transform infrared spectroscopy and immunoassay strips for fentanyl in a real‐world setting. Drug and alcohol review, 39(1), 98-102.

Gozdzialski, L., Wallace, B., & Hore, D. (2023). Point-of-care community drug checking technologies: an insider look at the scientific principles and practical considerations. Harm Reduction Journal, 20(1), 39.

Brandeis University: Massachusetts Drug Supply Data Stream

https://heller.brandeis.edu/opioid-policy/community-resources/madds/index.html

Washington State Community Drug Checking Network

https://adai.uw.edu/wordpress/wp-content/uploads/THE_DC_Network_Infosheet.pdf

To Combat the Opioid Crisis, Expand Drug Checking Programs
https://www.wired.com/story/to-combat-the-overdose-crisis-expand-drug-checking-programs/

New York State Department of Health Announces Drug Checking Programs

https://www.health.ny.gov/press/releases/2023/2023-10-23_drug_checking_programs.htm

British Columbia Centre on Substance Use: What is Drug Checking

https://drugcheckingbc.ca/what-is-drug-checking/

We Are the Loop: Our History

https://wearetheloop.org/our-history

Nixon Adviser Admits War on Drugs Was Designed to Criminalize Black People

https://eji.org/news/nixon-war-on-drugs-designed-to-criminalize-black-people/

Race and the War on Drugs

https://www.nacdl.org/Content/Race-and-the-War-on-Drugs

Otiashvili D, Mgebrishvili T, Beselia A, Vardanashvili I, Dumchev K, Kiriazova T, Kirtadze I. The impact of the COVID-19 pandemic on illicit drug supply, drug-related behaviour of people who use drugs and provision of drug related services in Georgia: results of a mixed methods prospective cohort study. Harm Reduct J. 2022 Mar 9;19(1):25. doi: 10.1186/s12954-022-00601-z. PMID: 35264181; PMCID: PMC8906357.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906357/

Emerging Drug Trends and Prevention

https://www.carnevaleassociates.com/our-work/emerging-drug-trends-prevention-issue-brief.html

Ray, B., Korzeniewski, S. J., Mohler, G., Carroll, J. J., Del Pozo, B., Victor, G., ... & Hedden, B. J. (2023). Spatiotemporal analysis exploring the effect of law enforcement drug market disruptions on overdose, Indianapolis, Indiana, 2020–2021. American journal of public health, 113(7), 750-758.

https://ajph.aphapublications.org/doi/10.2105/AJPH.2023.307291

Also referred to as point-of-care drug checking, community based drug checking refers to drug checking that is cited within overdose prevention centers, SSPs, and other harm reduction or community health settings. Compared to nightlife or pop-up drug checking, community based drug checking is more likely to be accessed by people who are structurally vulnerable to the harms of the War on Drugs and may be experiencing homelessness, complex medical concerns, and more chaotic substance use.

Within the context of drug checking, cross-reactivity refers to when a test responds inappropriately to the presence of a secondary compound that is not the primary target substance. For example, the presence of diphenhydramine (the active ingredient in Benadryl) can cause a false-positive result on a fentanyl test strip.

A memorandum of understanding (MOU) is a non-binding agreement between two or more parties that outlines how they will work together. MOUs are also known as letters of intent (LOIs) or memorandums of agreement (MOAs), and sometimes are the first step towards a formal contract.

Immunoassay strips are used to identify the presence or absence of a particular compound. The use specific antibodies to bind to the compound of interest. Immunoassay strips only give a positive or negative answer and do not indicate anything about how much of a particular compound is present. Examples of immunoassay strips commonly used in drug checking include fentanyl test strips, xylazine test strips, and benzodiazepine test strips, although tests are available for many other types of drugs.

The lowest concentration that can be confidently detected by an analytical instrument or technique.

An analytical instrument used to identify different compounds. Infrared spectroscopy uses infrared light to scan a sample, and then measures how the infrared light interacts with the various compounds in the sample.

A local drug supply refers to the localized aspects of drug availability within a specific area, encompassing unique variations in available drugs, adulterants, and distribution methods. These are impacted by regional law enforcement dynamics, community relationships, and targeted policies or interventions specific to that area.

Overdose Data to Action (OD2A) supports jurisdictions in implementing prevention activities and in collecting accurate, comprehensive, and timely data on nonfatal and fatal overdoses and in using those data to enhance programmatic and surveillance efforts. OD2A focuses on understanding and tracking the complex and changing nature of the drug overdose crisis by seamlessly integrating data and prevention strategies.

Following lawsuits against major pharmaceutical companies such as Perdue Pharma, opioid manufacturers and distributers are paying more than $54 billion in restitution for their role in the opioid overdose crisis. Much of this money has or will be given directly to state, county, or city governments but there is little guidance in how the money is to be spent.

An adulterant is a substance added to a drug to increase the bulk or weight of a drug, or to enhance the effects or the delivery of the drug in some way. Examples of common adulterants include xylazine, caffeine, diphenhydramine, and levamisole.

A method of determining the presence or absence of a specific compound using specific chemicals to elicit color changes within a solution. In drug checking, colorimetric analysis, also known as reagent testing, is used to assess for the presence or absence of a specific drug of interest. Results of the test are interpreted based on the observed color changes.